Molecular imaging of inflammation with PET in acute and ventilator-induced lung injury

Time course changes of oxidative stress and inflammation in hyperoxia-induced acute lung injury in rats

Objective(s):Therapies with high levels of oxygen are commonly used in the management of critical care. However, prolonged exposure to hyperoxia can cause acute lung injury. Although oxidative stress and inflammation are purported to play an important role in the pathogenesis of acute lung injury, the exact mechanisms are still less known in the hyperoxic acute lung injury (HALI).   Materials ...

Retracted: Time course changes of oxidative stress and inflammation in hyperoxia-induced acute lung injury in rats

Ventilator-induced lung injury.

From the Keenan Research Center, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, and the Department of Medicine and Interdepartmental Division of Critical Care Medicine, University of Toronto — both in Toronto (A.S.S.); and Dipartimento di Anestesia e Medicina degli Stati Critici, Ospedale S. Giovanni Battista Molinette, Università di Torino, Turin, Italy (V.M.R.). Address reprint requ...

Ventilator-induced lung injury.

Severe physical-trauma can lead to the development of acute respiratory distress syndrome (ARDS). Currently, the only known treatment for ARDS is mechanical ventilation. However, if mechanical ventilation is applied inappropriately further injury and malfunction of the lungs may occur, and thus, causing a ventilator induced lung injury (VILI). VILI has several manifestations including volutraum...

Ventilator-induced lung injury.

The clinical relevance of experimental ventilator-induced lung injury has recently received a resounding illustration by the Acute Respiratory Distress Syndrome Network trial that showed a 22% reduction of mortality in patients with acute respiratory disease syndrome when lung mechanical stress was lessened by tidal volume reduction during mechanical ventilation. This clinical confirmation of t...